Structure and receptor recognition of the sex pheromone ESP1 1 Structure of the Mouse Sex Peptide Pheromone ESP1 Reveals a Molecular Basis for Specific Binding to the Class-C G-Protein-Coupled Vomeronasal Receptor*
نویسندگان
چکیده
From the Faculty of Life Sciences, Kumamoto University, Chuo-ku, Kumamoto 862-0973, Japan, the Department of Applied Biological Chemistry and JST ERATO Touhara Chemosensory Signal Project, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan, and the Division of Physical Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan These authors contributed equally to this work
منابع مشابه
Molecular characterization of vomeronasal sensory neurons responding to a male-specific peptide in tear fluid: Sexual communication in mice
Pheromonal signals received by the vomeronasal organ (VNO) have been shown to elicit various behavioral and physiological responses that are typically stereotyped and preprogrammed. Recently, we found a novel male-specific peptide, named exocrine gland-secreting peptide 1 (ESP1), that is secreted in tear fluid and stimulates the VNO in mice. Excreted ESP1 appears to be transferred to the female...
متن کاملSelf-Exposure to the Male Pheromone ESP1 Enhances Male Aggressiveness in Mice
Exocrine gland-secreting peptide 1 (ESP1) released into male tear fluids is a male pheromone that stimulates sexually receptive behavior in female mice via the vomeronasal sensory system. ESP1 also induces c-Fos expression in male brain regions distinct from those in females. However, behavior in males following ESP1 exposure has not been examined. In the present study, we show that ESP1, in co...
متن کاملSex- and Strain-Specific Expression and Vomeronasal Activity of Mouse ESP Family Peptides
Male mice secrete exocrine-gland-secreting peptide 1 (ESP1) from the extraorbital lacrimal gland into tear fluid [1]. Other mice detect ESP1 through sensory neurons in the vomeronasal organ (VNO), a secondary olfactory system that senses pheromonal information, including sex, strain, and species. ESP1 is now known to be a member of a multigene family that encodes peptides of various lengths. We...
متن کاملA Labeled-Line Neural Circuit for Pheromone-Mediated Sexual Behaviors in Mice.
In mice, various instinctive behaviors can be triggered by olfactory input. Despite growing knowledge of the brain regions involved in such behaviors, the organization of the neural circuits that convert olfactory input into stereotyped behavioral output remains poorly understood. Here, we mapped the neural circuit responsible for enhancing sexual receptivity of female mice by a male pheromone,...
متن کاملThe Induction of Pregnancy Block in Mice by Bodily Fluids via the Vomeronasal Organ
Pheromones are chemical signals which provide conspecifics information about gender, dominance and reproductive status [1]. They elicit innate and stereotypical reproductive and social behaviors, along with neuroendocrine and physiological changes. The vomeronasal organ (VNO), as part of the accessory olfactory system, is the site for pheromone binding to specific receptors, thus initiating a s...
متن کامل